University of California San FranciscoNeuroimmunology & Glial Biology

Clinical studies / ReCOVER

ReCOVER

Evaluating clemastine as a potential remyelinating agent after acute optic neuritis.

UCSF lists as accepting participants

Checked October 6, 2026 · NCT02521311 · Phase 2

What is the study asking?

Evaluating clemastine as a potential remyelinating agent after acute optic neuritis. This is a randomized, double-blind, placebo-controlled study.

Clemastine is being investigated for myelin repair in this study; it is not approved for this use.

Participation at a glance

Approximate duration
9 months
Minimum visits
5 at UCSF
Typical visit
3 hours

Visit estimates below come from the existing Green Lab overview. Confirm the current schedule with the study team.

Study visit sequence

  1. Screening
  2. Week 1
  3. Month 1
  4. Month 3
  5. Month 9

The original lab overview describes random assignment to three months of clemastine or placebo, followed by evaluation at month nine.

Who may be eligible?

The official listing includes adults ages 18–55 with diagnosed or suspected acute demyelinating optic neuritis within three weeks of the onset of visual symptoms other than pain. Additional inclusion and exclusion criteria apply.

Read full criteria on UCSF Clinical Trials

The study team determines eligibility and explains the current protocol, potential risks, and consent process. This overview is not treatment advice.

Ask the study team

Use the official UCSF study page to check availability and contact the team.

Contact the ReCOVER study team

Sources: Green Lab study overview and UCSF Clinical Trials.